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"Operational Data" is data about how Vermeer equipment, services, and accessories incorporated on the equipment are performing with respect to particular jobs or other information regarding a customer's processes, operations, operators, jobs, job performance, and the work the customer performs with its Vermeer equipment. It may also include information or data that is input by a customer into a system or service provided by Vermeer. Accessories incorporated on the equipment include services, hardware, and software purchased or licensed by Vermeer from third parties for incorporation in, with, or on Vermeer equipment. Vermeer equipment also includes certain equipment that is branded as Vermeer or otherwise sold by Vermeer or its dealers for use with other Vermeer equipment, such as vacuum equipment and locator systems manufactured by third parties for or in conjunction with Vermeer

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Most of the routes listed here are found in two quarry holes that once made up Granite Railway Quarry. High Peak Railway Walks (Sheep Pasture To Middleton Bottom) The National Stone quarry Horse trough near Middleton Bottom. Right: Middleton Quarry Bottom to the quarry. A narrow gauge incline railway hauled wagons of stone Stone Mountain have been found near spur line to a

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Equally important to improving the performance of materials-handling machinery will be the development of new technologies for monitoring equipment status and for specific automation needs. In addition, for underground applications the interruption of the line of sight with satellites and thus the impossibility of using the GPS means a totally new technology will have to be developed for machine positioning

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Magnetic material is an essential ingredient in the separation process. Magnetic separation has benefited especially from robust development in the medical technology sector (e.g., in drug delivery) as well as from the developments of multifunctional magnetic materials. Iron oxide nanoparticles are generally recognized as safe (GRAS) and have been approved by the US Food and Drug Administration (FDA) for in vivo applications (Thanh, 2012; Punik et al., 2016). Furthermore, iron oxides are allowed as color and food additives according to the FDA. There are multiple studies on the toxicity and possible health effects of iron oxide nanoparticles: On the one hand, iron oxide nanoparticles are able to penetrate cells and produce reactive oxygen species (ROS) which can cause cell damage (Soenen et al., 2011; Liu et al., 2013). On the other hand, multiple studies do not indicate health effects of iron oxide nanoparticles (Szalay et al., 2012). This controversy and thus the potential toxicity of iron oxide nanomaterials need to be further investigated and evaluated in order to ensure safe handling of nanomaterials for applications such as magnetic separation (Auffan et al., 2009; Valdiglesias et al., 2015). The synthesis of different magnetic particles, especially at the nano level, as well as a broad number of magnetic particle functionalization strategies, have been presented by numerous reviews (Bergemann et al., 1999; Berensmeier, 2006; Lu et al., 2007; Laurent et al., 2008; Philippova et al., 2011; Buck and Schaak, 2013; Conde et al., 2014; Xiao et al., 2016; Ge et al., 2017). The synthesis method influences both the particle core and its surface properties (Laurent et al., 2008; Shavel and Liz-Marzn, 2009; Roth et al., 2015). For iron oxides alone, multiple strategies ranging from co-precipitation to hydrothermal synthesis and from milling to biological synthesis are known (Laurent et al., 2008; Ali et al., 2016). Superparamagnetic nanoparticles can be used for separation processes as-synthesized or embedded in polymer matrices, often leading to microcarriers (Philippova et al., 2011). These microcarriers (Table 2) represent the most commonly used and commercially available particles for magnetic separation applications (Berensmeier, 2006; Borlido et al., 2013; Fields et al., 2016). Nanoparticles have an advantage over microparticle beads and chromatography resins as there is no mass transfer limitation for protein diffusion in the separation process, which is important in terms of capacity, purity, level of contamination and processing time. Non-embedded magnetic nanoparticles, such as bare iron oxide nanoparticles, have a great potential for separation processes due to their low production costs, the abundance of precursors, and their high density. On the other hand, magnetic microbeads are easier to handle in separation processes as they are less prone to magnetic aggregation effects. Thus, the larger size facilitates a better ratio between magnetic force and Stokes's drag force leading to a better severability in magnetic fields compared to colloidally stabilized nanoparticles. The selection of the optimal magnetic material depends strongly on the process strategy. Target biomaterial and process conditions also play a crucial role in the choice of the beads (see Figure 1). Depending on the prize and the requirements of the target product, either low-cost crude bare iron oxide nanoparticles or highly specific adsorbents, such as protein A modified magnetic particles, need to be used for purification processes (Holschuh and Schwmmle, 2005; Gomes et al., 2018; Schwaminger et al., 2019a,b). Furthermore, the conditions for binding and elution of the target protein must be accurately chosen with regard to the beads chemistry and process design. The functionalization of magnetic surfaces is a toolkit which can be adapted to the properties of the target and the selected switch conditions between adsorption and desorption. In summary, depending on the application, the magnetic material, the particle size, the stabilization and functionalization need to be selected and combined (Figure 3)

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